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The site has been occupied by chemical industries for decades but most of the old works were demolished in the 1980s and replaced by a computer centre, offices and a car park.
Areas to be treated include part of the northern area of the site occupied by a car park serving the Hexagon Tower and computer centre and mounds on the south side south formed by materials excavated when the computer centre was built.
The River Irk lies to the east of the site along with a residential area and land off Slack Road which has been granted planning permission for 300 homes.
A public footpath sits in the south of the site and to the west is North Manchester General Hospital.
Decontamination works will involve removing material and filling excavations with clean material and grassing over the affected areas.
A temporary water treatment plant, offices and laboratory will be set up during the remedial works and a new permanent river wall will be built.
The works are aimed at removing the risk from trichlorobenzine (TCB) which has been entering the river and removbe the risk to humans walking in the area.
The Environment Agency says there may be more contamination on the north car park site which is not being investigated yet could present a risk.
The Environment Agency is demanding further investigation into this area.
During the remedial works it was planned to monitor dust emissions into the atrmosphere once a week.
The head of Manchester?s environmental health department is demanding daily checks for dust and odours.
All heavy good vehicles leaving the site must be covered and will be permitted only to travel via Mill Brow, Slack Road and Factory Lane to Rochdale Road on route to a licensed landfill site in Pilsworth, Bury.